Novel TRPV1 antagonist

Novel ROS1 kinase inhibitor

Novel ROS1 kinase inhibitor

Novel potent and selective inhibitor of kir1.1 channels

Novel inducer of the ISG54 promoter, causing IRF-3 translocation

Novel Max-binding modulator, attenuating Myc-driven transcription and stabilizing the Max homodimer

Novel KIF18A inhibitor, causing significant mitotic arrest in vivo, binding at the interface of KIF18A and tubulin

Novel FGFR2 inhibitor, enhancing the chemosensitivity of drug-resistant gastric cancer cell lines

Novel anti-inflammatory and antioxidant agent, significantly decreasing blood glucose, triglycerides, and cholesterol and increased insulin

Inhibitor of Aβ-induced inflammation

Novel Pim-1 kinase Inhibitor, dose-dependent decreasing the viability of LS174T and HCT-116 cells

Novel potent peptide dual agonist of opioid/neurokinin 1 receptor

Novel and potent factor Xa inhibitor

Potent and selective adenosine A1 antagonist with renal protective and diuretic activities

Phosphate acceptor peptide substrate for cAMP-dependent protein kinase

Potent and selective KDM5 inhibitor

Potent and selective KDM5 inhibitor

Novel KDM4 inhibitor

Novel selective KDM4C inhibitor

Potent PDZ domain peptide inhibitor that rescues CFTR activity

Novel potent and Subtype-Selective Positive Modulator of KCa2 Channels

Dual PDE3/4 inhibitor

Highly specific transglutaminase 2 (TG2) inhibitor

LTB4 inhibitor for the treatment of b-cell leukemias and lymphomas, potently inhibiting histamine, platelet activating factor,and 5-lipoxygenase

Novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the in

Novel highly potent dual amylin and calcitonin receptor agonist (DACRA), showing long-lasting improvement of food preference and body weight loss

Selective inhibitor of Protein_kinase_D1>protein kinase D (PKD); Inhibitor of cell adhesion and HIV; Inhibitor of herpes simplex virus type 1 replication

Novel Plk1 PBD inhibitor, showing a remarkable in vitro anticancer effect by inducing Plk1 delocalization, mitotic arrest, and apoptosis in HeLa cells

Novel histone deacetylase inhibitor

Novel activator of hERG1 potassium channels, blocking native and recombinant hERG1 channels at high voltages, but activating them at low voltages