Novel potent and highly selective GPR6 inverse agonist, inhibiting GPR6 cAMP signalling in TR-FRET assays with a EC50 = 16 nM and >100 fold selectivity against GPR3 and GPR12

Novel selective inhibitor of activated fibroblasts, inhibiting the enhanced migration of fibroblasts cocultured with cancer cells by binding to β-arrestin1 and interfering with β-arrestin1-mediated cofilin signaling pathways

Novel potent and selective SIRT2 inhibitor, increasing the acetylation level of eukaryotic translation initiation factor 5A (eIF5A) and reducing cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression

Natural selective inhibitor of protein tyrosine phosphatases (PTPases)

Novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities

Novel potent Liver Receptor Homolog-1 (LRH-1) modulator

Highly selective α4β2 subtype nicotinic receptor agonist

Novel peroxisome proliferator-activated receptor gamma (PPARgamma) agonist

Novel IAP-based selective RIPK2 degrader

First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific inhibitor

Natural inducer of apoptosis by significantly upregulating Bcl-2, mitigating expression of Bcl2 in HCT 15 cells and attenuating the apoptotic markers and cell cycle regulatory proteins

Novel antidiabetic agent, impairing glucose uptake by muscle tissue, excessing hepatic gluconeogenesis, and increasing beta-cell apoptosis

HIV-1 reverse transcriptase inhibitor, also acting as an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor

Natural antibiotic, inhibiting prokaryotic DNA-dependent RNA synthesis and protein synthesis; blocking RNA-polymerase transcription initiation, modulating ß2m aggregation

Antibiotic for tuberculosis (TB) treatment

Selective antagonist of the serotonin 5-HT3 receptor

Potent inhibitor of the Rho pathway

Selective sigma-2 ligand, inducing apoptosis in EMT-6 breast cancer cells

Quorum sensing modulator as a RhlR antagonist

Novel potent and selective RhlR antagonist, strongly inhibiting biofilm formation, and reducing production of virulence factors in P. aeruginosa

Quorum sensing modulator as a RhlR agonist

Potent tubulin assembly and cancer cell growth inhibitor

Novel Insect growth regulator, as potential insecticide to control olive fruit fly (Bactrocera oleae Rossi)

Novel inhibitor of the human papillomavirus (HPV) E6 oncoprotein

Potent inhibitor of Kv1.5 potassium channel

Novel Potent and Stable Antagonist of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain

Orally active, selective dopamine D3 receptor partial agonist

Novel peptide-drug conjugate, inducing significant tumor growth suppression with negligible toxicity

Novel avß6 selective arginyl-glycinyl-aspartic acid (RGD)-mimetic, demonstrating to bind with extremely high affinity and selectivity for the alphavß6 integrin and having the potential as a clinical tool and therapeutic for investigating the role of avß6

Potent, selective & ATP-competitive inhibitor of Cdks