A potent positive allosteric modulator (PAM) on the three KAR subunits GluK1b, GluK2a, and GluK3a. BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold, and noticeably decreases desensitization kinetics (from 5.5 to 775 ms).

Dopamine antagonist, also having antihistaminic and anticholinergic properties

MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome

TAAR1 agonist, for the short-term treatment of obesity

A potent, selective and orally bioavailable c-Met inhibitor

Novel Inhibitor of Smoothened (Smo) signaling

Inhibitor of the proliferation of cancer cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21WAF1/Cip1 expression

Potent, non-peptide delta-opioid receptor agonist.

Novel specific antagonist of the thyroid-stimulating hormone receptor (TSHR)

Potent whole-cell active inhibitor of biotin biosynthesis