Potent inhibitor of TANK-binding kinase-1 (TBK1)/IKKepislon kinases

Novel highly potent A3 adenosine receptor (A3AR) antagonist with Kd values (nM): 0.55 (human), 3.74 (mouse), and 2.80 (rat)

Novel Partial Agonist of Human and Mouse A3 Adenosine Receptors (Ki = 10.9/17.8 nM, at human/mouse A3AR)

Novel highly selective A1 adenosine receptor (A1AR) agonist

Bitopic fluorescent antagonist of the A2A adenosine receptor

Novel potent P2Y14 Receptor Antagonist (IC 50 , 15 nM)

Novel potent antagonist of P2Y 14 receptor (P2Y 14 R) (IC 50 ~20 nM at hP2Y 14 R/mP2Y 14 R)

Novel highly potent human CD73 inhibitor (K i = 0.673 nM)

Potent and selective P2Y6 receptor agonist

Potent P2Y6 agonist

Selective P2Y2 agonist

Selective P2Y6 agonist

Potent P2Y14 receptor agonist

Selective enhancer of the ATP effects at fast desensitizing P2X (P2X1 and P2X3) receptors

Novel selective and reproducible inhibitor of DNA synthesis in E. coli JL553

Novel potent and selective RORγT inhibitor, showing no appreciable activity against a panel of related nuclear hormone receptors

Novel potent RORγT inhibitor

Novel potent and selective RORγT inhibitor, showing no appreciable activity against a panel of related nuclear hormone receptors

Novel peripheral CB1R antagonist, being highly biased toward inhibiting CB1R-induced β-arrestin-2 (βArr2) recruitment over G-protein activation

Activator of MrgX1 receptor signaling

Novel positive allosteric modulator (PAM) of mas-related G protein-coupled receptor X1 (MRGPRX1), reducing behavioral heat hypersensitivity in humanized MRGPRX1 mice, demonstrating the therapeutic potential in treating neuropathic pain

Novel inhibitor of the main protease (Mpro) of SARS-CoV-2

Novel, potent inducer of apoptosis via the MAP kinase pathways. Inhibitor of several kinases including the tyrosine kinase FLT3-ITD

Novel highly potent and selective 5-HT2C agonist

Novel potent and selective antagonist of GluN2A-containing NMDA receptors

Novel mitochondrial permeability transition pore (mPTP) inhibitor

Novel Dual HDAC6 and Tubulin Inhibitor, Displaying Anti-tumor Ability in Human Cancer Cells

Novel tubulin polymerization inhibitor

Novel inhibitor of MPS1

Novel Mps1 Kinase Inhibitor